アイルランドにおける呼吸器シンチチアルウイルス (RSV) からの乳児の保護:ニルセビマブ予防接種全国プログラムの影響, 2024/2025年

Laura Paris¹, Lisa Domegan², Maureen O'Leary²

¹European Centre for Disease Prevention and Control (ECDC) Fellowship Programme, Field Epidemiology path (EPIET), ECDC, Stockholm, Sweden; Health Service Executive- Health Protection Surveillance Centre, Ireland.

Vaccine

|February 14, 2026

まとめ

アイルランドアイルランドアイルランド

科学分野:

公衆衛生は公衆衛生である.
免疫学免疫学とは
小児科は小児科です.

背景:

アイルランドは2024/2025シーズンに呼吸器同胞性ウイルス (RSV) に対する全国予防接種プログラムを導入しました.
2024年9月から2025年2月間に生まれた乳児は,RSV予防のための長時間作用するモノクローナル抗体であるニルセビマブを受ける資格がありました.

研究の目的:

アイルランドの適格な乳児のRSV関連疾患の減少におけるニルセビマブ免疫プログラムの有効性を評価する.

主な方法:

遡及的,人口ベースの生態学的研究では,2024/2025シーズンのRSV症例と臨床結果を分析しました.
2024/2025年のデータと過去RSVシーズン (2023/2024年と2022/2023) を比較した.
予防された症例,病気を予防した分数,および免疫に必要な数 (NNI) を調整された式を用いて計算した.

主要な成果:

適格な乳児の83%が2024/2025シーズンにニルセビマブを受けた.
RSV症例は2023/2024シーズンと比較して68%,2022/2023シーズンと比較して64%減少しました.
このプログラムにより,1055件のRSV症例,459件の救急診療,437件の入院,76件のICU入院が回避され,予防比率は74.5%となった.

結論:

ニルセビマブ予防接種は,2024/2025シーズンのアイルランド人の乳児のRSV関連罹患率を著しく低下させた.
この結果は,ニルセビマブの継続的な使用を支持し,高齢の乳児集団への潜在的な拡大を示唆しています.

キーワード:

ワクチン接種の影響乳幼児の予防接種についてニールセビマブ (Nirsevimab) とは - コトバンク予防接種に必要な数 (NNI)呼吸器シンチチアルウイルス (RSV)

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