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Updated: Feb 16, 2026

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
07:55

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP

Published on: October 17, 2015

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細胞標的タンパク質薬の細胞内密輸のKDEL媒介調節

Eric Voltà-Durán1, Lorena Alba-Castellon2, Lourdes A Arena3

  • 1Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Plaça Cívica s/n, Bellaterra, Barcelona 08193, Spain; Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), C/ Violinista Vellsolà 37, Terrassa, Barcelona 08222, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona 08193-08041, Spain.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|February 14, 2026
PubMed
まとめ

細胞を標的とするタンパク質薬は,リソソームの分解に直面する. KDELモチーフを付着させることで,これらの薬物をエンドプラズマ網膜に誘導し,その安定性と抗がん活性性を高めます.

キーワード:
プロテイン・ドラッグは,タンパク質薬です.タンパク質エンジニアリングは,標的の薬物投与をターゲットにします.

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