カーバペネム耐性エシェリキア・コーライに対するプラゾミシンの活性:簡潔な報告
Priti Kambli1, Shaoli Basu1, Susan Rodrigues1
1Department of Laboratory Medicine (Microbiology), P. D. Hinduja National Hospital and Medical Research Centre, Mumbai, India.
Indian journal of medical microbiology
|February 14, 2026
まとめ
プラゾミシンは,一般的な耐性遺伝子を持つカルバペネム耐性大腸菌 (CR-E. coli) を効果的に治療しました. しかし,新しい16S rRNAメチルトランスファーゼ (RMTs) はプラゾミシンを著しく減少させます.
科学分野:
- * 感染症
- * 微生物学について
- * 抗菌剤耐性について
背景:
- *カルバペネム耐性エシェリキア大腸菌 (CR-E. coli) は,世界的に治療に重大な課題を抱えています.
- *新種の耐性メカニズムの出現により,抗生物質の有効性の継続的な評価が必要となる.
- *アミノグリコシド変異酵素 (AME) と16S rRNAメチルトランスフェラーゼ (RMTs) は,耐性を与える重要なメカニズムである.
研究 の 目的:
- *ムンバイのCR-E. coli単離体に対するプラゾミシンのインビトロ活性を評価する.
- *カルバペネマゼ,AME,RMTを含む特定の耐性遺伝子のプラゾミシンの感受性に対する影響を調査する.
主な方法:
- * 最低抑制濃度 (MIC) の決定を用いた52のCR-E. coli単離体の感受性試験.
- * NDM,OXA-48型カルバペネメーゼ,AME,RMT (例えば,rmtB1,rmtC,rmtF1) を含む耐性遺伝子の特徴づけ
主要な成果:
- *プラゾミシンは,NDMまたはOXA-48型のカルバペネメーゼを宿すCR-E. coliに対して,AMEsの有無にかかわらず強力な活性 (MICs 0.19-2 mg/L) を示した.
- *16S rRNAメチルトランスフェラーゼ (RMTs) を発現する単離体は,プラゾミシンに対する高レベルの耐性を示した (MIC ≥256 μg/mL).
結論:
- *プラゾミシンは,AMEsを伴うが,RMTを欠くCR-E. coli菌株に対する有望な治療法である.
- * RMT媒介による耐性の出現は,プラゾミシンおよび他のアミノグリコシドの臨床的有用性に重大な脅威をもたらす.
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