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Updated: Feb 16, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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ATF5はLPAR5を活性化し,マクロファージの炎症性反応を強化し,関節リウマチ症を悪化させる

Caijie Liu1, Yingnan Guo1, Yanni Dong1

  • 1Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, PR China.

Biochemical pharmacology
|February 14, 2026
PubMed
まとめ

リソホスファティド酸受容体5 (LPAR5) は,ATF5/LPAR5/PI3K/AKT経路経由で炎症性マクロファージの反応を増幅することで,リウマチ性関節炎 (RA) を促進する. このカスケードをターゲットにすることで,RAの新たな治療法を提供できるかもしれません.

キーワード:
活性化トランスクリプション因子5リソホスファティド酸受容体5 リソホスファティド酸受容体5マクロファージは,マクロファージのPI3K/AKTシグナリングリウマチ性関節炎 (Rheumatoid arthritis) とは,関節のリウマチ性関節炎 (Rheumatoid arthritis) とは,関節のリウマチ性関節炎 (Rheumatoid arthritis) とは,関節のリウマチ性関節炎 (Rheumatoid arthritis) とは,関節のリウマチ性関節炎 (Rheumatoid arthritis) とは,関節のリウマチ性関節炎 (Rheumatoid arthritis) とは,関節のリウマチ性関節炎 (Rheumatoid arthritis) とは,

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