PPP4Cは,MST4のリン酸化を調節することで,YAP1の活動を回復させ,免疫抑制を強化し,非小細胞肺がんの腫瘍増殖を促進します

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Zhengshui Xu1, Jiani Gao2, Changchun Ye3

  • 1Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China; Key Laboratory of Surgery Critical Care and Life Support (Xi'an Jiaotong University), Ministry of Education, Xi'an, Shaanxi, 710061, China.

Cancer letters
|February 14, 2026
PubMed
まとめ

哺乳類のステリル20型キナーゼ4 (MST4) は,非小細胞肺がん (NSCLC) の発現量が少なく,腫瘍の成長と免疫回避を抑制する. PPP4Cによる降解はNSCLCを促進し,MST4とPPP4Cを潜在的な治療標的として強調しています.

キーワード:
免疫逃避という免疫逃避です.MAP4K2K2 についてMST4 (MST4) についてNSCLCLCは,NSCLCLCは,NSCLCLCは,NSCLCLCは,NSCLCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCは,NSCLCはPPP4Cは,PPP4Cとして利用されています.YAP1 YAP1 YAP1 YAP1 YAP1 YAP1 YAP1

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