抗生物質耐性および感染症性内心炎における安全性:高齢の患者に重点を置く

Capucine Richard¹, Sylvain Gautier², Pierre Boisson DE Chazournes³

¹Geriatrics department, University Hospital A. Paré, Versailles St Quentin University, APHP, Boulogne-Billancourt, France.

Infectious diseases now

|February 14, 2026

まとめ

感染症性内心炎 (IE) の高齢者は抗生物質をよく耐えるが,認知障害は有害事象のリスクを増大させる. 年齢自体は,IE患者の抗生物質耐性の主要な要因ではありません.

科学分野:

心臓病学心臓病学
感染症感染症は感染症です.
ゲリアトリクスゲリアトリクス

背景:

感染症性内心炎 (IE) は,高死亡率の重症疾患で,高齢者に不釣り合いな影響を及ぼします.
高齢のIE患者における抗生物質耐性に関するデータは限られている.

研究の目的:

IEと診断された65歳以上の患者の抗生物質耐性を評価するために.
この集団における抗生物質関連の有害事象 (AE) に関連する要因を特定する.

主な方法:

パリ地区の65歳以上のIE患者の病院ネットワークコホート研究 (2016年5月 - 2024年8月).
追跡から6ヶ月以内に,抗生物質関連の有害事象を体系的に収集する.

主要な成果:

83人の患者の25.3%がAEを経験した; 認知機能障害は,特に≥75.75の患者で,より高いAEリスクと関連していた.
AEsは,より長い入院期間と関連していたが,年齢,自律性,入院の結果の違いはなかった.
アモキシチリンとセファゾリンはしばしばAEに関与していたが,ストリプトコッカIEはAEを少なく示した.

結論:

高齢のIE患者の抗生物質耐性は一般的に良好です.
年齢だけではなく,認知状態が,高齢のIE患者における抗生物質関連の有害事象の主要な予測因子です.

キーワード:

薬剤の有害事象は,薬剤の有害事象である.認知障害認知障害感染性エンドカルディチス (感染性エンドカルディチス)多科目の介護です.高齢者の高齢者は,

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