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Updated: Feb 16, 2026

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury
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脳由来ニューロトロフィック因子およびその由来ドデカペプチドは,急性肺損傷におけるトール型受容体4の抗体として機能する

Weiwei Zhu1,2,3, Leiming Jin2, Qianhui Zhang2

  • 1Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Nature communications
|February 14, 2026
PubMed
まとめ

脳由来神経栄養因子 (BDNF) レベルは,急性肺損傷中に低下し,炎症に寄与します. BDNFの回復,またはその断片であるBDP-12の使用は,マクロファージのトール型受容体4 (TLR4) を標的にすることで炎症を軽減します.

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