ラクトバチルス・デルブルエッキイ亜種. bulgaricus 2038とStreptococcus thermophilus 1131は,ポリチレンナノプラスチックの細胞間浸透性を抑制し,腸内皮質細胞によって内部化されます
Kyosuke Kobayashi1, Miho Ogawa2, Junko Mochizuki3
1Wellness Science Labs, Meiji Holdings Co., Ltd., Tokyo, Japan. kyousuke.kobayashi@meiji.com.
Scientific reports
|February 14, 2026
まとめ
ヨーグルトの特定のバクテリア株,ラクトバシルス・デルブルエッキイ亜種. bulgaricus 2038とStreptococcus thermophilus 1131は,有害なナノプラスチックがヒト細胞に侵入するのを防ぐことができます. この発見は,ナノプラスチックに関連する健康リスクを軽減するための潜在的な戦略を提供します.
科学分野:
- 環境科学 環境科学
- 微生物学 微生物学とは
- 毒理学 毒理学 毒理学
背景:
- ナノプラスチックはヒトの健康に有害で,細胞に侵入し,酸化ストレスやアポトーシスなどの損傷を引き起こす.
- ナノプラスチックの内部化を防止する現在の方法は不十分であり,公衆衛生上の重大な懸念を引き起こしています.
研究 の 目的:
- 特定のプロバイオティック菌株,ラクトバチルス・デルブルエッキイ亜種の可能性を調査する. bulgaricus 2038とStreptococcus thermophilus 1131は,ナノプラスチックの吸収を防ぐのに役立ちます.
- これらのバクテリア菌株のナノプラスチックの内部化と細胞間透過性を減らす効果を評価する.
主な方法:
- 人間の腸内障壁をシミュレートするために,微分化されたCaco-2細胞単層モデルを使用しました.
- ナノプラスチックの内部化を定量化するために,フローサイトメトリと免疫光染色を用いた.
- 耐性菌株と非耐性菌株の両方をテストし,ナノプラスチックの吸収への影響を評価しました.
主要な成果:
- L. bulgaricus 2038 と S. thermophilus 1131 は,Caco-2 細胞によるポリステレンナノプラスチック (PSNP) の内部化を有意に抑制しました.
- 抑制効果は,生命力のない細菌株でも観察されました.
- これらの菌株はまた,PSNPの細胞間浸透性を著しく低下させ,全身分布の減少を示唆した.
結論:
- L. bulgaricus 2038とS. thermophilus 1131は,ナノプラスチックの内部化を防止し,関連する健康リスクを軽減する大きな可能性を示しています.
- 菌株に依存する有効性は,治療上の応用のために特定の細菌株の重要性を強調しています.
- これらの発見は,ナノプラスチックの毒性に対抗するために特定のプロバイオティクスを使用する新しいアプローチを示唆しています.
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