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Updated: Feb 16, 2026

Engineering and Evolution of Synthetic Adeno-Associated Virus AAV Gene Therapy Vectors via DNA Family Shuffling
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Published on: April 2, 2012

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プログラムされた in vivo Treg 拡張により,AAV 遺伝子治療に対する免疫反応を抑制する

Lavesh Gwalani1, Mincheol Park1, Alexandra B Ysasi1

  • 1Sanofi, Genomic Medicine Unit, Waltham, MA.

Molecular therapy : the journal of the American Society of Gene Therapy
|February 15, 2026
PubMed
まとめ

THOR-834は,改変されたインタールイキン-2 (IL-2) で,アデノ関連ウイルス (AAV) 遺伝子治療の有効性を改善するために,調節性T細胞 (Tregs) を拡張します. この新しいアプローチは免疫反応を抑制し,トランスゲン発現の持続性を高めます.

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