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One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model01:12

One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

403
Extravascular administration, such as oral or intramuscular routes, is a non-invasive drug delivery method, often preferred for ease and patient compliance. A key factor here is absorption, which dictates how quickly and effectively the drug enters the bloodstream from the administration site. Absorption follows either zero-order or first-order kinetics.
Zero-order absorption maintains a steady rate irrespective of the amount of drug left to be absorbed, making it a constant process. In the...
403
One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model01:15

One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

588
The first-order absorption model for extravascular administration describes the rate at which a drug is absorbed and eliminated, following the principles of first-order kinetics. This model is vital as it provides a mathematical representation of drug behavior within the body. It also allows for the prediction and interpretation of drug absorption and elimination based on the rate of change in drug concentration over time. This model can be visualized as a plasma concentration-time profile...
588
Drug Absorption: Factors Affecting GI Absorption01:19

Drug Absorption: Factors Affecting GI Absorption

6.4K
The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
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Growth Models with Integration: Problem Solving01:27

Growth Models with Integration: Problem Solving

65
In population modeling, integration provides a systematic way to determine accumulated quantities from known rates of change. One such application arises in ecology, where the total weight of a fish population in a body of water is referred to as its biomass. When the rate of growth of this biomass is known as a function of time, calculus can be used to determine the total biomass at a future date.Growth Rate and Biomass FunctionLet the growth rate of the fish population be represented by a...
65
Thermal expansion and Thermal stress: Problem Solving01:27

Thermal expansion and Thermal stress: Problem Solving

2.2K
San Francisco's Golden Gate Bridge is exposed to temperatures ranging from -15 °C to 40 °C. At its coldest, the main span of the bridge is 1275 m long. Assuming that the bridge is made entirely of steel, what is the change in its length between these temperatures?
To solve the problem, first, identify the known and unknown quantities. The initial length (L) of the bridge is 1275 m, the coefficient of linear expansion (α) for steel is 12 x 10-6/°C, and the change in temperature (ΔT) is 55...
2.2K
Protection of Alcohols02:31

Protection of Alcohols

8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
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Updated: Feb 16, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

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超連続放射線下でのブロードバンドレーザー保護反射器のスペクトル統合熱吸収モデル

Yukang Feng1,2, Yanzhi Wang1,2, Yulin Zhang1,2

  • 1Laboratory of Thin Film Optics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Science, Shanghai, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 15, 2026
PubMed
まとめ

強力なレーザーは標的を損傷しますが,ナノメートルの多層コーティングは保護を提供します. 新しいモデルでは,短波長を優先する反射器がレーザーエネルギーの吸収を最適に管理し,ブロードバンドレーザー保護のために温度上昇を低減することを示しています.

キーワード:
レーザーコーティングは,超連続レーザーは,超連続レーザーです.温度の上昇 温度の上昇薄膜デザインです.

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Last Updated: Feb 16, 2026

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科学分野:

  • 光学とフォトニック
  • 材料科学 材料科学とは
  • レーザー物理学 レーザー物理学

背景:

  • 強力な多波長レーザーは,価値あるターゲットに熱損傷を与えます.
  • 高反射率のナノメートルスケールの多層コーティングは,レーザー保護に不可欠です.
  • 多波長照射下におけるこれらのコーティングの熱反応とそのブロードバンド保護能力に関する研究は限られている.

研究 の 目的:

  • ナノメートルの多層塗料のための普遍的なレーザーエネルギー吸収モデルを開発する.
  • 超ブロードバンド全ダイエレクトリックナノメートルの多層反射器の設計と実験的検証を行う.
  • 超連続レーザー照射下での熱反応と保護メカニズムを調査する.

主な方法:

  • スペクトル強度統合に基づく新しい普遍的なレーザーエネルギー吸収モデルを提案した.
  • 設計された超ブロードバンド全ダイエレクトリックナノメートルの多層反射器 (450~1200 nmの平均反射率>99.9%).
  • 超連続レーザー照射下での反射器温度を実験的に評価し,シミュレーションのために有限元法を使用した.

主要な成果:

  • エネルギー吸収モデルは,2つの吸収係数によって特徴づけられる指数関数分解の振る舞いを明らかにしました.
  • 短波の吸収は,長波の吸収よりも気温上昇に大きく寄与する.
  • 短波長優先反射器は最小の温度上昇を示し,ブロードバンドレーザー保護に有効であることが証明されました.

結論:

  • 開発されたモデルは,実験データによって検証されたレーザー照射下で反射器の温度上昇を正確に予測します.
  • 短波長優先リフレクターは,ブロードバンドレーザー保護に非常に有効です.
  • 発見は,レーザー保護反射器の熱評価と設計のための貴重な洞察を提供します.