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Updated: Feb 17, 2026

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S1PR3アンタゴニズムは,ROCK1-Drp1シグナル伝達経路を通じて,セプティック急性腎臓損傷における内皮機能障害を改善する

Zhipeng Xu1, Jueyue Yan1, Gan Luo2

  • 1Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Molecular immunology
|February 15, 2026
PubMed
まとめ

スフィンゴシン-1-フォスファート受容体3 (S1PR3) は,内皮細胞とミトコンドリアを損傷することによって,腎臓損傷を誘導します. 脂質体薬でS1PR3を阻害すると,腎臓機能が保護され,セプシス誘発の急性腎臓損傷が軽減されます.

キーワード:
敵対する相手.細胞内皮細胞 (endothelial cell) とは,細胞内皮細胞 (endothelial cell) とは,細胞内皮細胞 (endothelial cell) とはリポソームはリポソームである.ミトコンドリアはミトコンドリアです.S1PR3S1PR3S1PR3S1PR3S1PR3S1PR3S1PR3S1PR3S1PR3S1PR3S1PR3S1PR3S1PR3S1セプティック急性腎臓損傷

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