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Updated: Feb 17, 2026

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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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2014年から2024年までの新生児性セプシス:グラム陰性ロッドの復活
Noa Fleiss1, Thomas S Murray1, Richard S Feinn2
1Department of Pediatrics, Yale School of Medicine, New Haven, CT; Yale New Haven Children's Hospital, New Haven, CT, USA.
The Journal of pediatrics
|February 15, 2026
まとめ
新生児のセプシスは,グラム陰性病原体,特に大腸菌の増加を示し,死亡率の増加につながります. この傾向は,低妊娠年齢と重度の高い病気と組み合わせて,新生児集中治療室 (NICU) のアウトカムに影響を与えます.
科学分野:
- 新生児医学 新生児医学
- 感染症 感染症は感染症です.
- 公衆衛生は公衆衛生である.
背景:
- 新生児性セプシスは,世界的に,罹病率と死亡率の重要な原因であり続けています.
- 進化する病原体傾向とリスク要因を理解することは,新生児のアウトカムを改善するために不可欠です.
研究 の 目的:
- 新生児性セプシスの発生率,病原体,臨床的特徴,および2014年から2024年までのアウトカムを評価する.
- 現在のデータと過去の機関記録を比較する.
- 1928年以来の新生児のセプシスの長期的な傾向を分析する.
主な方法:
- 血流感染症の乳児の遡及コホート研究 (2014-2024年).
- 予期的なエピソードのドキュメンテーションと予期的なデータ収集.
- 2つの時代 (2004年~2013年 vs. 2014年~2024年) を比較した単変数および複数回帰分析.
主要な成果:
- 233人の乳児 (2014-2024) で250回のセプシスエピソード.
- 早期発症性セプシス (EOS) のグラムネガティブ生物の増加,特にE. coli,特に遅い早産/期間の新生児およびVLBWの乳児.
- 遅発性セプシス (LOS) の発生率は低かったが,重症度と死亡率は増加した (11%から25%),グラム陰性細菌は50% (2020-2024) に上昇した.
- セプシスに関連した死亡率は30年以上にわたって着実に増加し,予測要因には出生体重の低下,プレッサーの使用,NEC,および血小板閉塞が含まれています.
結論:
- EOSとLOSの両方に,グラム陰性病原体,特にE. coliの持続的な増加.
- 妊娠年齢の低下と発症時の重度の上昇は,セプシス関連の死亡率の上昇に寄与しています.
- 新生児性セプシスの流行病学的変化に対処するために,緊急の戦略が必要である.
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