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Updated: Feb 17, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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クラスIのHDACをターゲットにすることで,腫瘍原性の脆弱性を抑制し,KRAS変異がんにおけるKRAS/MAPK経路阻害剤を強化する

Kexin Yang1, Xiaolong Qin2, Yafang Wang3

  • 1Lingang Laboratory, Shanghai 201101, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Journal of advanced research
|February 15, 2026
PubMed
まとめ

クラスIのHDAC阻害剤は,臓がんや結腸直腸がんなどのKRAS変異がんに対して有望であり,p53機能を回復させ,c-Mycを退廃させることで薬剤耐性を克服します. この表遺伝的アプローチは,臨床試験を正当化しています.

キーワード:
クラスIのHDACはIHCH903333 についてクラス・クラス (Kras Kras) とはMYC (マイク) とはP53 P53 P53 P53 P53 P53 P53 P53 P53 P53YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP

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