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仮想スクリーニングに基づく新しいPPARαアゴニストの設計,合成,および活性評価

Yutong Niu1, Weinan Wang2, Yiqian Xie1

  • 1School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, China; Zhejiang Key Laboratory of Intelligent Drug Discovery and Development, School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, UCAS, Hangzhou 310024, China.

Bioorganic & medicinal chemistry letters
|February 15, 2026
PubMed
まとめ

研究者らは,ペロキソーム増殖器活性化受容体α (PPARα) を活性化させる強力な新しい化合物XYQ3-B11を発見し,脂質不全症の治療法の開発に有望な新しい方向性を提供しました.

キーワード:
PPARαアゴニストである.構造変化による構造変化シンセシス シンセシス仮想スクリーニング

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