自己免疫性および免疫媒介性関節炎の生物学的治療におけるバイオマーカーおよび標的としての腸内微生物群 - 系統的レビュー
Madhumitha Rondla1, Mohamed Sayed Zaazouee2, Arya Akhila Perumangote Vasudevan3
1M. Rondla, MD, Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.
The Journal of rheumatology
|February 15, 2026
まとめ
生物学的治療は,自己免疫性関節炎における腸内微生物群を変化させ,有益な細菌を促進し,有害な細菌を減少させます. 特定の微生物は,治療の成功と疾患の活性に対するバイオマーカーとして機能する可能性があります.
科学分野:
- 免疫学 免疫学とは
- 微生物学 微生物学とは
- 胃腸内科 胃腸内科
背景:
- 腸内微生物群のディスバイオシスは,自己免疫性関節炎の病原化に関連しています.
- 生物学的物質は腸内微生物群に影響を与える可能性があるが,そのメカニズム (直接か間接か) は不明である.
- 腸内微生物群に対する生物学的影響を理解することは,治療の最適化に不可欠です.
研究 の 目的:
- 生物学的療法が自己免疫性関節炎における腸内微生物群を調節する方法を体系的に検討する.
- 治療への反応と疾患の活性に対するバイオマーカーとしての腸内微生物群の可能性を調査する.
主な方法:
- PubMed,Scopus,コクラン図書館,Web of Scienceの体系的な文献検索を行いました.
- 免疫媒介性または自己免疫性関節炎における生物療法によって誘発された腸内微生物群の変化を評価する研究を含む.
- 結果は,微生物群の変化とその予測バイオマーカーとしての可能性に焦点を当てました.
主要な成果:
- 12件の研究では,生物学的薬 (抗TNF,IL-17阻害剤) が腸内微生物群の組成と多様性を変化させることを明らかにしました.
- 治療により,アルファ多様性が増加し,ベータ多様性が正常化し,有益な分類種 (例えば,Faecalibacterium prausnitzii) が回復し,炎症性遺伝子が減少しました.
- LachnospiraceaeやMegamonasのような特定の分類は,臨床改善と疾患の活動低下と相関していました.
結論:
- 生物学的治療は,自己免疫性関節炎において腸内微生物群をユーバイオシスへとシフトさせます.
- 特定の微生物系 (Lachnospiraceae, Blautia, Faecalibacterium prausnitzii) は,非侵襲的なバイオマーカーとして有望であることを示しています.
- 臨床応用のための微生物シグネチャーを検証するためにさらなる研究が必要である.
関連する概念動画
Genome-wide Association Studies-GWAS
15.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.8K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
600
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
600
Inflammatory Bowel Disease IV: Pharmacological Management
795
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
795
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
561
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
561
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
915
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
915
Autoimmune Disorders
1.9K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.9K


