CTIと様々なトリグリセリド・グルコース肥満系指数と関節炎との関連:NHANESデータベースに基づく横断分析
Yibo Lin1,2, Haimei Zhong1,2, Zilong Wen3
1Dongguan Key Laboratory of Chronic Disease Prevention and Control, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, 523710, China.
European journal of medical research
|February 15, 2026
まとめ
カステリ・トマッシニ指数 (CTI) やTyG-WHtRのような肥満指標は,関節炎のリスクが高いことと関連しています. TyG-WHtRは,関節炎の発生に関する強力な予測能力を示しています.
科学分野:
- エンドクリノロジー エンドクリノロジー
- レウマトロジーの病理学
- 公衆衛生は公衆衛生である.
背景:
- 関節炎は,インスリン抵抗性 (IR) と炎症の影響を受けます.
- カステリ・トマッシニ指数 (CTI) は,IRと炎症を評価するための新しいマーカーです.
- TyG指数とそのBMI,腰周,腰と身長比率の導出物を含む肥満指標も関与しています.
研究 の 目的:
- CTIと関節炎の関連性を調査する.
- 関節炎の発生に関するTyG指数および関連する肥満指標の予測的差異を比較する.
主な方法:
- NHANESデータ (2001年−2010年) を用いた横断的な研究.
- pondered logistic regressionとRestricted Cubic Spline (RCS) のモデルが採用されました.
- 分析には,値効果,サブグループ分析,相互作用テスト,ROC曲線分析が含まれていました.
主要な成果:
- CTIは関節炎と正の関連性を示した (P <0.05).
- TyG,TyG-BMI,TyG-WC,およびTyG-WHtRは関節炎と陽性に関連していた.
- TyG-WHtRは,最も優れた診断効果を示した (AUC = 0.629).
結論:
- CTI,TyG-BMI,TyG-WC,およびTyG-WHtRは関節炎と陽性に関連しています.
- TyG-WHtRは,関節炎に対するより強い予測能力を示しています.
- CTIは,特に若年成人において,早期の関節炎リスクの識別に有効なバイオマーカーとして役立つ可能性があります.
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