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Updated: Feb 17, 2026

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サブタイプ固有のサーチューイン発現シグネチャーは,ミトコンドリア-エピジェネティックネットワークと乳がん生存率を結びつける

Zoltan Ungvari1,2, Otília Menyhárt3,4,5, Alberto Ocana6,7

  • 1Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

GeroScience
|February 15, 2026
PubMed
まとめ

サートゥイン (Silent mating type information regulation 2の同類) は,高齢化と乳がんにおける重要な調節因子である. 多遺伝子サーチューインパネルは,乳がんサブタイプにおける再発性のない生存率を効果的に予測し,治療上の脆弱性を明らかにします.

キーワード:
老化とがんのインターフェース老化と癌について乳がん 乳がんは乳がんです.コエクスプレッションネットワークは,共表現ネットワークです.エピジェネティック・レギュレーション,サブタイプ固有のシグネチャーゲロアンコロジー (Geroncology) とは長寿遺伝子は長寿遺伝子のことです.ミトコンドリアのシグナル伝達多遺伝子シグネチャーのサインNAD+の代謝 NAD+の代謝予測モデルとは,予測モデルである.再発のない生存率サーチューインズ (Sirtuins) とはトランスクリプトミックの統合

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