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Updated: Feb 17, 2026

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
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Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples

Published on: December 2, 2022

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ギブスの自由エネルギーの変化がトポイソメラーゼ-IBの活性を調節する:分子動力学とMM/GBSAの研究

Muralidhar1, Rakesh Kumar Tiwari1, Vipin Kumar Mishra2

  • 1Department of Physics, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur, India.

Journal of biomolecular structure & dynamics
|February 16, 2026
PubMed
まとめ

人間のトポイソメラーゼ-IB酵素は,アミノ酸からのギブスの自由エネルギーを利用して,DNAの断裂を安定させる. リジン-318は,細胞プロセス中のDNA処理と酵素構成の変化に不可欠です.

キーワード:
ギブスは自由エネルギーである.MM/GBSA MM/GBSA について溶媒にアクセシブルな表面積は残留物ごとに結合エネルギーがある.制御された回転回転.

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