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Updated: Feb 17, 2026

Harvesting and Cryo-cooling Crystals of Membrane Proteins Grown in Lipidic Mesophases for Structure Determination by Macromolecular Crystallography
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Harvesting and Cryo-cooling Crystals of Membrane Proteins Grown in Lipidic Mesophases for Structure Determination by Macromolecular Crystallography

Published on: September 2, 2012

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固着性GPCRにおけるステロイド認識:構造的および薬理学的視点

Bethany Fleming1, Abdul-Akim Guseinov1, Irina G Tikhonova2

  • 1Centre for Translational Pharmacology, School of Molecular Biosciences, University of Glasgow, Glasgow, UK, Scotland.

Pharmacology research & perspectives
|February 16, 2026
PubMed
まとめ

ステロイドは,粘着性Gタンパク質結合受容体 (GPCRs) に結合し,有望な薬物標的クラスである可能性があります. 構造的研究はADGRD1にステロイド結合ポケットがあることを明らかにし,GPCRsの間で共通の認識メカニズムを示唆しています.

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Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs09:45

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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