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Updated: Feb 17, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

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人間のDNAポリメラーゼ ηは,相互排他的モノ-ウビキチン化とモノ-NEDDylationによって調節されます

Natália C Moreno1,2, Emilie J Korchak3, Marcela T Latancia1

  • 1Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3371, United States.

Nucleic acids research
|February 16, 2026
PubMed
まとめ

DNAポリメラーゼエタ (Pol η) は,ユビキチン型のタンパク質 NEDD8.8 によって調節されます. このモノ-NEDDylationは,Pol ηが紫外線で照射された細胞で焦点を形成するのを防止し,転移DNA合成に影響を与えます.

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