関連する実験動画

Updated: Feb 17, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

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DNA オリガミの複雑な協力性は,設計に依存した欠陥によって明らかになった

Jacob M Majikes1,2, Amna Hasni3, Shankar Haridas4

  • 1Theiss Research, La Jolla, CA 92037, United States.

Nucleic acids research
|February 16, 2026
PubMed
まとめ

研究者は,異なるデザインと生産量の測定によって,DNA オリガミの組み立て協力性を調査しました. 彼らは,熱安定性と折り畳み協力性を組み立ての成功と相関させる予測パラメータを開発し,設計のベストプラクティスの洞察を提供しました.

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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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DNA Topoisomerases02:02

DNA Topoisomerases

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Topoisomerases are divided into two main types. ...
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
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