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Updated: Feb 17, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

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エリグルスタートとC2-epi-エリグルスタートの非対称的総合合成

Miguel Mellado-Hidalgo1, Anna M Costa1, Pedro Romea1

  • 1Department of Inorganic and Organic Chemistry, Section of Organic Chemistry, and Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Carrer Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain.

The Journal of organic chemistry
|February 16, 2026
PubMed
まとめ

研究者らは,eleglustatとC2-epi-eliglustatの並列非対称合成を開発しました. キラルニッケル (CHIRAL NICKEL) 触媒を用いた重要なステレオ制御反応により,エナティオメリックに純粋な製品の分離が可能になった.

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Sharpless Epoxidation02:57

Sharpless Epoxidation

The conversion of allylic alcohols into epoxides using the chiral catalyst was discovered by K. Barry Sharpless and is known as Sharpless epoxidation. The use of a chiral catalyst enables the formation of one enantiomer of the product in excess. This chiral catalyst is mainly a chiral complex of titanium tetraisopropoxide and tartrate ester (specific stereoisomer). The stereoisomer used in the chiral catalyst dictates the formation of the enantiomer of the product. In other words, the use of...
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Thermal Electrocyclic Reactions: Stereochemistry

The stereochemistry of electrocyclic reactions is strongly influenced by the orbital symmetry of the polyene HOMO. Under thermal conditions, the reaction proceeds via the ground-state HOMO.
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
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