ダウン症候群と認知症患者の認知機能の評価:体系的なレビュー
Ana Clara Lira do Nascimento1, Egeval Pereira da Paz1, Graziela Rosa Lopes Bastos Freire1
1Universidade de Pernambuco, School of Medicine, Group of Geriatrics, Recife PE, Brazil.
Dementia & neuropsychologia
|February 16, 2026
まとめ
ダウン症候群 (DS) の個人は認知症,しばしばアルツハイマー病 (AD) を経験する. 早期診断は困難ですが,行動の変化はDSにおける認知症の発症の兆候となる可能性があります.
科学分野:
- 神経学 神経学とは
- 遺伝学 遺伝学とは
- 精神科医は精神病を患っている.
背景:
- ダウン症候群 (DS) の個人は,アルツハイマー病 (AD) を含む認知症を発症するリスクが著しく高くなります.
- 認知症における既にある認知の違いの存在は,認知症の早期かつ正確な診断を複雑にします.
- 認知症集団における認知症に合わせた特定の診断基準の必要性が極めて高い.
研究 の 目的:
- ダウン症候群の個体における認知および行動的認知症の症状を定義する.
- DSにおける認知症の診断のための既存の認知評価ツールの有用性と適性を批判的に評価する.
主な方法:
- 主要データベース (PubMed,Scopus,Web of Science,BVS) で2014年から2024年までPRISMAのガイドラインを遵守して,体系的な文献検索が行われました.
- 英語,ポルトガル語,またはスペイン語で出版された研究は含まれ,その質はSTROBE基準を使用して評価されました.
- 254件の記録をスクリーニングした後,合計28件の研究が含まれました.
主要な成果:
- DSにおける早期発症性認知症は,執行機能,記憶,言語,注意力の低下によって特徴付けられます.
- 興奮,幻覚,無関心などの重大な行動の変化が頻繁に観察されます.
- これらの行動症状は,アルツハイマー病ダウン症候群 (AD-DS) とプロドラム性認知症の段階の両方で顕著に見られ,早期の指標としての可能性を示唆しています.
結論:
- ダウン症候群の患者における認知症は,認知能力と行動能力の低下の明確なパターンを表しています.
- 行動症状は,DS集団における認知症の重要な早期診断マーカーとして浮上しています.
- 認知症における認知症の早期発見と管理を改善するために,さらなる研究と特定の診断ツールが必要です.
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