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Updated: Feb 17, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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リウマチ性関節炎におけるシナヴィアル炎症と治療抵抗の原動力としての肝細胞成長因子

Quang Minh Dang1,2,3, Ryu Watanabe1, Takeshi Iwasaki4

  • 1Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.

Frontiers in immunology
|February 16, 2026
PubMed
まとめ

肝細胞成長因子 (HGF) は,シノヴィアル線維芽細胞を活性化し,フィードバックループを作成することによって,関節リウマチ症 (RA) の炎症を誘発します. HGF-c-Met経路をサボリチニブで標的にすることは,RAの治療と治療抵抗性の克服に有望であることが示されています.

キーワード:
肝細胞成長因子 (HGF) が肝細胞の成長因子である.インターレウキン-6 (IL-6)リウマチ性関節炎 (rheumatoid arthritis) とは,関節のリウマチ性関節炎 (rheumatoid arthritis) とは,関節のリウマチ性関節炎 (rheumatoid arthritis) とは,関節のリウマチ性関節炎 (rheumatoid arthritis) とは,シノヴィアル・フィブロブラストトール型受容体 (toll-like receptor) とは,トール型受容体 (toll-like receptor) とは,トール型受容体 (toll-like receptor) とは,トール型受容体 (toll-like receptor) とは,トール型受容体 (toll-like receptor) とは,トール型受容体 (toll-like receptor) とは,

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