3-ヒドロキシステアール酸は,コレステロールの流出を促進し,ALKBH5/PAX-8/ABCA1経路経由で動脈硬化症を緩和します

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Updated: Feb 17, 2026

Cholesterol Efflux Assay
07:54

Cholesterol Efflux Assay

Published on: March 6, 2012

30.7K

Qin-Yi Zhou1, Wang Liu2, Zhen-Wang Zhao3

  • 1Key Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Department of Cardiology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Frontiers in immunology
|February 16, 2026
PubMed
まとめ

腸内微生物群の代謝産物である3-ヒドロキシステアール酸 (C18-3OH) は,ALKBH5/PAX-8/ABCA1経路を調節することによって,発泡細胞のコレステロール流出を増強する. この発見は,動脈硬化症に対する新しい治療戦略を提供する.

キーワード:
3ヒドロキシステアール酸は,3ヒドロキシステアール酸ATP結合カセットトランスポーターA1 A1動脈硬化症 (動脈動脈硬化症) についてコレステロール 流出 流出ペアリングボックスタンパク質 8 8α-ケトグルタレート依存型ダイオキシゲンアースアルクBホモログ5

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