表面麻酔剤が舌の感覚機能に与える影響
Mami Takemori1, Mika Honda-Sakaki2, Wakana Nakamoto3
1Department of Anesthesiology, Nihon University School of Dentistry at Matsudo, Chiba, JPN.
Cureus
|February 16, 2026
まとめ
ベンゾカイン (BEN) とリドカイン水塩化物 (LDCA) は,舌の先端に類似した麻酔効果を示しています. この研究では,感覚機能への影響を比較し,BENが燃える口症候群 (BMS) 治療の有効な選択肢である可能性を示唆しました.
科学分野:
- 口服薬は,口服薬として使われます.
- 薬理学 薬理学とは
- 感覚科学は,感覚に関する科学です.
背景:
- 燃える口症候群 (BMS) は,しばしばリドカイン塩化水素 (LDCA) で治療される状態です.
- BMSの治療と検査におけるベンゾカイン (BEN) の有効性は,さらなる調査を必要としています.
- 定量的な感覚検査は,局所麻酔薬が口腔の感覚知覚に及ぼす影響を評価するために使用されます.
研究 の 目的:
- 燃える口症候群 (BMS) の治療法としてベンゾカイン (BEN) の可能性を評価する.
- ベンゾカイン (BEN) とリドカイン水塩化物 (LDCA) が舌先の感覚機能に及ぼす麻酔効果を比較する.
- これらの麻酔薬が機械検知値 (MDT),機械疼痛値 (MPT),数値評価スケール (NRS) のスコアに与える影響を調査する.
主な方法:
- 30人の健康な女性を対象とした単盲,ランダム化クロスオーバー研究.
- 2%のLDCA,20%のBEN,および3つの異なる日にわたって舌の先端にバゼリンコントロールを適用します.
- MDT,MPT,およびNRSの測定は,ベースラインおよび適用後の複数の時間点で行われます.
主要な成果:
- 2%のLDCAと20%のBENの両方が,立即および適用後15分まで,ベースライン値と比較してMDTを大幅に増加させた.
- 両方の麻酔剤でMPTの有意な増加が観察され,LDCAは30分,BENは15分まで効果を示した.
- 測定期間と試験した麻酔薬の間で,NRSスコアに有意な差は認められなかった.
結論:
- 2%のLDCAと20%のBENは,健康な舌先の感覚機能に類似した麻酔効果を示しています.
- ベンゾカイン (BEN) は,口腔炎症症候群 (BMS) のような状態の有効な代替または補助治療として役立つ可能性があります.
- これらの発見をBMS患者で確認するためにさらなる研究が必要である.
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