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Updated: Feb 17, 2026

Analyzing the α-Actinin Network in Human iPSC-Derived Cardiomyocytes Using Single Molecule Localization Microscopy
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Analyzing the α-Actinin Network in Human iPSC-Derived Cardiomyocytes Using Single Molecule Localization Microscopy

Published on: November 3, 2020

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細胞の形状と成熟は,iPSC由来心筋細胞におけるα-アクチニン-2張力に影響する

Palash K Dutta, Joshua M Toth1, Subramanian Sundaram2

  • 1Center for Engineering Mechanobiology and Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

APL bioengineering
|February 16, 2026
PubMed
まとめ

心筋細胞 (CM) の収縮には,サルコメアを通して力の伝達が含まれます. この研究では,新しいセンサーを用いて,細胞の形状と成熟が,サルコメリックタンパク質α-アクチニン-2の緊張に影響を及ぼし,心臓の機能に影響を及ぼすことを示しました.

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