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Updated: Feb 17, 2026

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
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Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

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知識の風景からネットワークメカニズムへ:ALSにおける制御細胞死経路を図示する

Jingxuan Zhang1, Zilin Zhao2, Tianyue Xiang2

  • 1First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, China.

Frontiers in aging neuroscience
|February 16, 2026
PubMed
まとめ

アミオトロフィック横筋硬化症 (ALS) と調節細胞死 (RCD) に関する研究は拡大しており,相互に関連した経路を明らかにしています. バイオインフォマティクスと図書館計測は,免疫代謝シグナリングを重要な収束点として特定し,フェロプトーシス,炎症,および潜在的治療標的のオートファギーを強調しています.

キーワード:
アミオトロフィック横筋硬化症オートファジー (Autophagy) とは文献数学的分析による分析バイオインフォマティックスフェロプトーシス (ferroptosis) とは免疫メタボリズムミトコンドリアの機能障害神経炎症による神経炎症です.

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Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Protein Networks

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The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
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Apoptosis01:30

Apoptosis

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Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
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