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Updated: Jul 6, 2026

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分子ドッキングベースのスクリーニングを通じて,FGFRを標的とする小分子阻害剤の特定

Weibo Hou1, Kun Liu2, Ping Wang1

  • 1College of Bioinformatics Science and Technology, National Health Commission Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, Heilongjiang, China.

Frontiers in oncology
|February 16, 2026
PubMed
まとめ

我々は,フィブロブラスト成長因子受容体 (FGFRs) を標的とする新しい小分子阻害剤であるZINC000101867325を特定しました. この化合物は,FGFRシグナリングを効果的に阻害し,結腸直腸がん細胞の増殖を減少させ,アポトーシスを増加させます.

キーワード:
CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC,CRC.FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは,FGFRsは分子ドッキングドッキングです.分子ダイナミクスのシミュレーションです.小分子阻害剤 小分子阻害剤

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