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Updated: Feb 17, 2026

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
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IREB2におけるD826V点変異は,脂肪組織におけるリポゲネシスを誘発する

Yibing Lv1,2, Chunyu Wu3, Junyi Xiao4

  • 1Henan Provincial Key Laboratory of Genetic Diseases and Functional Genomics and Medical Genetics Institute of Henan Provincial People's Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in cell and developmental biology
|February 16, 2026
PubMed
まとめ

Ireb2D826V/D826V変異は,鉄の蓄積とIREB2タンパク質の分解を引き起こし,脂質の生物合成と体重の増加につながります. これは,鉄代謝と肥満の間の関連性を示唆し,潜在的な治療目標を提供している.

キーワード:
IREB2は,IREB2で,IREB2は,IREB2で,IREB2は,IREB2で,IREB2は,IREB2で,IREB2は,IREB2で,IREB2は,IREB2は,IREB2は,IREB2は,IREB2は,IREB2は,IREB2は,IREB2は,IREB2は,IREB2は,IREB2は脂肪酸の脂肪酸は,脂肪酸でできている.フェリチニンはフェリチニンです.脂質バイオシンセシストリグリセリドは,トリグリセリドを

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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