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関連する概念動画

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Nerve Supply of the GI Tract01:27

Nerve Supply of the GI Tract

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The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
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Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

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The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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関連する実験動画

Updated: Feb 17, 2026

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
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Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

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腸内神経系と炎症性腸疾患について

Shixian Wang1, Yufeng Wang2, Ji Miao1

  • 1Division of Colorectal Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, P. R. China.

Gastroenterology report
|February 16, 2026
PubMed
まとめ

腸内神経系 (ENS) または"第2の脳"は,腸の健康にとって極めて重要です. 腸の機能不全は炎症性腸疾患 (IBD) と大腸がんを誘発しますが,ENSをターゲットにすることで新たな治療の可能性が生まれます.

キーワード:
結腸直腸がん 結腸直腸がん 結腸直腸がん腸内膠質細胞 (enteric glial cells) とは,腸内膠質細胞 (enteric glial cells) と呼ばれている.腸内神経系 腸内神経系腸内ニューロン 腸内ニューロン炎症性腸疾患とは神経免疫クロストーク

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科学分野:

  • 神経胃腸内科 神経胃腸内科
  • 免疫学 免疫学とは
  • 腫瘍学 腫瘍学

背景:

  • 腸の"第2の脳"である腸神経系 (ENS) は,胃腸機能とホメオスタシスを調節する.
  • ENS機能不全は,炎症性腸疾患 (IBD) の病原化に関与しています.

研究 の 目的:

  • ENSとIBDの複雑な相互作用をレビューする.
  • ENSが腸内ホメオスタシス,炎症,結腸直腸がんにおける役割を強調する.
  • IBDと結腸直腸癌のENSを標的とした新興の治療戦略について議論する.

主な方法:

  • 胃腸の健康と疾患におけるENS機能に関する既存の文献のレビュー.
  • 実験的な大腸炎モデルにおける神経免疫交響メカニズムの分析.
  • 結腸直腸癌の発達と進行に対するENSの貢献の検討.

主要な成果:

  • IBDの患者は,炎症と障壁機能不全を悪化させる腸内神経疾患を発症します.
  • 腸内膠質細胞 (EGCs) は,腸内ホメオスタシスの重要な調節体であり,慢性炎症や癌に関連した機能障害があります.
  • 神経免疫クロストラックは大腸炎に大きく影響し,ENSは神経生成と侵入を通じて結腸直腸がんに影響します.
  • ENSの活動を標的とする新興療法がIBDの症状緩和に有望であることを示しています.

結論:

  • ENSはIBDの病原性および結腸直腸がんの進行における重要な要因です.
  • ENS内の神経免疫相互作用をターゲットにすることは,胃腸疾患の有望な治療法である.
  • ENSを完全に理解し,治療上の利益のために活用するために,さらなる研究と学際的なアプローチが必要である.