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関連する概念動画

Pharmacovigilance01:19

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Drug Toxicity: Risk factors01:24

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Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
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Combined Effects of Drugs: Synergism01:27

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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Therapeutic Drug Monitoring: Affecting Factors01:29

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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Updated: Feb 17, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
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レクリエーション用薬物使用と,フランスにおける入院後の心血管疾患との関連

Raphael Mirailles1,2,3, Clément Delmas4, Solenn Toupin1,2

  • 1Université Paris-Cité, Service de Cardiologie, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, France (R.M., S.T., J.-G.D., P.H., T.P.).

Circulation. Population health and outcomes
|February 16, 2026
PubMed
まとめ

レクリエーション用薬物使用は,1年以内に心臓病重症病棟 (ICCU) の患者において,主要な有害心血管および脳血管イベント (MACCE) のリスクを大幅に高めます. これは,この高リスク集団に対して標的を絞った介入の必要性を強調しています.

キーワード:
心血管疾患 心血管疾患薬物使用者,薬物使用者人間,人間,人間,人間.発生頻度 発生頻度集中治療室には集中治療室があります.予後予測 予後予測レクリエーション用薬物使用

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科学分野:

  • 心臓病学 心臓病学
  • クリニック・リサーチ 臨床研究
  • 公衆衛生は公衆衛生である.

背景:

  • レクリエーション用薬物使用は,心臓病重症病棟 (ICCU) の入院結果と関連しています.
  • 急性心臓発作後のレクリエーション用薬物使用による心血管疾患への影響については,さらなる調査が必要である.

研究 の 目的:

  • 主要な不良心血管および脳血管イベント (MACCE) に対するレクリエーション用薬物使用の1年間の予後効果を評価する.
  • ICCU患者におけるレクリエーション用薬物使用とMACCEとの関連性を評価する.

主な方法:

  • 1,392人のICCU患者さんを対象とした,前向きな多センターのADDICT-ICCU研究.
  • 入院時に尿経薬物検査を体系的に実施し,MACCE (心血管疾患による死亡,心筋梗塞,脳卒中) の1年間の追跡調査を行った.
  • 多変量コックス回帰分析は,従来の予後要因に調整されています.

主要な成果:

  • 11.3%の患者がレクリエーション用薬物 (大麻,オピオイド,コカインなど) の検査で陽性でした. ) を実施する.
  • 1年間のMACCE発生率は,薬物使用者 (12.7%) と非使用者 (6.0%) の間で高かった.
  • レクリエーション用薬物使用,特に大麻とオピオイドは,独立してMACCEを予測した (HR 2.91).

結論:

  • レクリエーション用薬物使用は,ICCU入院後1年以内に有害な心血管疾患のリスクを大幅に増加させます.
  • リクリエーション用薬物使用歴のあるICCU患者にとって,ターゲットを絞った介入は不可欠です.