Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

4.2K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
4.2K
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

1.0K
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
1.0K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

7.7K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
7.7K
Overview of the Vascular System01:20

Overview of the Vascular System

3.6K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.6K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

5.8K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
5.8K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

619
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
619

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Heart failure promotes gingival inflammation and impairs periodontal remodeling.

Scientific reports·2026
Same author

Unhealthy fat distribution as a sex-specific predictor of declining hippocampus insulin sensitivity.

Diabetologia·2026
Same author

Myths and misconceptions about high-sensitivity C-reactive protein as a marker of residual inflammatory risk.

European heart journal·2026
Same author

Very strong correlations of metoprolol- and solanidine-derived metabolic ratios in a real-world cohort with a stable metoprolol drug regimen.

Frontiers in pharmacology·2026
Same author

Effect of Finerenone on Albuminuria in Type 1 Diabetes by Baseline HbA1c Level and Diabetes Duration: An Exploratory Analysis of the FINE-ONE Trial.

Diabetes care·2026
Same author

Cancer prevention through metabolic remission.

Nature reviews. Endocrinology·2026

関連する実験動画

Updated: Feb 17, 2026

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
07:00

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

Published on: February 26, 2019

10.1K

GLP-1と心血管系について

Florian Kahles1, Andreas L Birkenfeld2,3,4,5, Nikolaus Marx1

  • 1Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen, Aachen, Germany.

The Journal of clinical investigation
|February 16, 2026
PubMed
まとめ

グルカゴンのようなペプチド-1受容体アゴニスト (GLP-1RAs) は,高リスク患者の心血管疾患のアウトカムを改善します. 経口GLP-1RAとGIP/GLP-1ダブルアゴニストは,糖尿病と心血管疾患のリスクを管理するためのさらなる治療的進歩を提供します.

さらに関連する動画

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
09:16

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

Published on: April 20, 2017

16.1K
Precision Cut Lung Slices as an Efficient Tool for Ex vivo Pulmonary Vessel Structure and Contractility Studies
09:08

Precision Cut Lung Slices as an Efficient Tool for Ex vivo Pulmonary Vessel Structure and Contractility Studies

Published on: May 24, 2021

7.0K

関連する実験動画

Last Updated: Feb 17, 2026

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
07:00

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

Published on: February 26, 2019

10.1K
Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
09:16

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

Published on: April 20, 2017

16.1K
Precision Cut Lung Slices as an Efficient Tool for Ex vivo Pulmonary Vessel Structure and Contractility Studies
09:08

Precision Cut Lung Slices as an Efficient Tool for Ex vivo Pulmonary Vessel Structure and Contractility Studies

Published on: May 24, 2021

7.0K

科学分野:

  • 内分泌学と新陳代謝について
  • 心血管疾患に関する研究
  • 薬理学 薬理学とは

背景:

  • グルカゴン型ペプチド-1 (GLP-1) は,グルコース代謝を調節する重要なホルモンです.
  • GLP-1受容体 (GLP-1R) 経路の活性化は,2型糖尿病の治療標的である.
  • インクレチンベースの治療には,ディペプチジルペプチダゼ4 (DPP-4) 阻害剤とGLP-1受容体アゴニスト (GLP-1RAs) が含まれる.

研究 の 目的:

  • GLP-1とGLP-1RAsの心血管効果をレビューする.
  • 心血管疾患または高心血管リスクを有する患者のGLP-1RAに関する臨床データをまとめます.
  • インクレチンベースの治療法における進歩について,経口製剤および二重アゴニストを含む議論する.

主な方法:

  • GLP-1,GLP-1RAs,および心血管のアウトカムに関する既存の文献のレビュー.
  • DPP-4阻害剤とGLP-1RAsを含む大規模な心血管結果試験 (CVOTs) のデータの分析.
  • 二重GLP-1R/GIPRアゴニストであるティルゼパチドの臨床試験結果の検討.

主要な成果:

  • DPP-4阻害剤は,CV安全性を示すが,CVイベントの減少は示していない.
  • いくつかのGLP-1RAs (リラグルチド,セマグルチド,ドゥラグルチド) は,CVOTにおけるCVアウトカムの有意な減少を示しています.
  • 経口GLP-1RAとGIP/GLP-1ダブルアゴニストは,HbA1cの減少と体重減少において有効性を高める新しい治療戦略を表しています.

結論:

  • GLP-1RAsは,好ましい心血管プロファイルを持ち,高リスク集団におけるCVイベントを軽減します.
  • 経口GLP-1RAおよび二重アゴニストを含むインクレチンベースの治療法の進歩は,改善された血糖制御と体重管理を提供します.
  • 継続的なCVOTは,ティルゼパチドのような新しい薬剤の長期的な心血管への影響を評価するために不可欠です.