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Updated: Feb 18, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

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薬剤投与のためのポリ・2-オクサゾリンの調整:COSMO-RS経由でAPI互換性を予測する

Alžběta Zemánková1, Alex Mathers1, Fatima Hassouna2

  • 1Department of Physical Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.

International journal of pharmaceutics
|February 16, 2026
PubMed
まとめ

Conductor-like Screening Model for Real Solvents (COSMO-RS) は,ナプロクセンの溶解性について,ポリ・2-オクサゾリン (POx) の溶解性を正確に予測しています. リアルなポリマーモデルにより,予測が改善され,薬剤エキシピエントの早期配方スクリーニングが促進されます.

キーワード:
アモルフな固体の分散形である.コスモ・RSは,コスモ・リサーチ・システム (COSMO-RS) と呼ばれる.薬物ポリマーの互換性段階図 (Phase Diagram) についてポリー (((2-オクサゾリン)シンセシス シンセシス

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