関連する実験動画

Updated: Feb 18, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

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将来の仮想クロスオーバーおよび並列試験を通じて,即時放出型ヴォルティオキセチンの錠剤の生物同等性の予測に成功しました

Dorota Danielak1, Marcela Staniszewska1, Svitlana Romanova2

  • 1Physiolution Polska, 74 Piłsudskiego St., 50-020 Wrocław, Poland.

Journal of pharmaceutical sciences
|February 16, 2026
PubMed
まとめ

バーチャル・バイオエキワレンスの試験は,ヴォルティオセチンの臨床試験設計をガイドした. クロスオーバーバーチャル生物同等性試験は100%の生物同等性を正確に予測したが,並列試験ではより大きなサンプルサイズが必要だった.

キーワード:
生物学的同等性についてバイオ医薬品 バイオ医薬品クリニック・トライアル・シミュレーションインシリコモデリング薬剤の投与は口服によるものです.ファルマコキネティクス生理学ベースのバイオ医薬品のモデリング

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