代謝可能なタンパク質の供給が中期乳児乳牛のCD4+Tリンパ球の代謝機能に与える影響
U Arshad1, T Fernandez-Wallace1, R Fukumori1
1Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison 53706.
Journal of dairy science
|February 16, 2026
まとめ
乳牛のサブ最適メチオニンとタンパク質 (MP) 供給は,CD4+Tリンパ球の代謝機能と持続性を低下させた. この代謝障害は,早期授乳などの栄養失調時に免疫反応を損なう可能性があります.
科学分野:
- 動物科学 動物科学
- 免疫学 免疫学とは
- 栄養バイオケミストリー
背景:
- 中期の乳母牛は,免疫細胞機能に影響を与える栄養上の課題に直面しています.
- CD4+Tリンパ球は,適応免疫に不可欠であり,その代謝状態は,その有効性に影響します.
- 食事中のタンパク質の供給は,牛の全体的な健康と免疫能力に影響を与える重要な要因です.
研究 の 目的:
- 乳牛の非活性化 (NA) と活性化 (AC) のCD4+Tリンパ球の代謝機能に対するメチオニンとタンパク質 (MP) の供給の変動の影響を調査する.
- 不十分なMP供給がミトコンドリアの呼吸とCD4+T細胞の糖分解に影響するかどうかを判断する.
- MP供給がT細胞の持続性とATP生成に及ぼす影響を評価する.
主な方法:
- 哺乳期半ばのホルシュタイン牛32頭は,MPに適したまたは不適した食事を12週間にわたって与えられました.
- 周辺血液の単核細胞を隔離し,その後CD4+Tリンパ球を磁気隔離した.
- 代謝機能 (酸素消費率,細胞外酸化率,陽子流出率) は,NAおよびAC条件下で細胞外流量分析を使用して評価されました.
主要な成果:
- 不十分なMPダイエットを受けた牛は,NAとACのCD4+Tリンパ球の両方で酸素消費率の低下と最大呼吸率を示した.
- 不十分なMP供給は,有酸素糖解の漸進的な低下と時間経過とともにT細胞の持続につながった.
- 総ATP生成は影響を受けなかったが,NA CD4+Tリンパ球と比較して,ACにおけるグリコリティックATP生成は高かった.
結論:
- 低最適のMP供給は,乳牛におけるCD4+Tリンパ球の代謝能力と持続性を損なう.
- 栄養失調によるT細胞の代謝機能の低下は,免疫反応を損なう可能性があります.
- 適切なMP供給を維持することは,栄養ストレスのある時期に免疫細胞機能をサポートするために不可欠です.
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