関連する実験動画

Updated: Feb 18, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

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SARS-CoV-2のエントリーにおけるコレステロール依存性膜融合の分子機構

Wei Li1, Mengdan Wu1, Shirong Feng1

  • 1National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Signal transduction and targeted therapy
|February 16, 2026
PubMed
まとめ

コレステロールは,スパイクタンパク質のクラスタリングとウイルスのドッキングを促進することによって,重症急性呼吸器症候群コロナウイルス2 (SARS-CoV-2) の侵入を高めます. このメカニズムは,コレステロールがスパイクタンパク質のC端のシステイン豊富な領域と相互作用し,膜融合を促進します.

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SNAREs and Membrane Fusion

Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
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