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Updated: Feb 18, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

11.3K

TRPA1はNLRP3炎症ゾームを活性化させ,ピロプトーシスを誘発することで,過活性の膀の進行を促進します

Yongjuan Rao1,2, Yunran Wang1, Jie Gao1

  • 1School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Cell death & disease
|February 16, 2026
PubMed
まとめ

過活動性膀 (OAB) は炎症を伴う. この研究では,一時受容体潜在アンキリン-1 (TRPA1) がNLRP3炎症体とピロプトーシスを活性化し,OABの進行を促すことが示されています. TRPA1またはNLRP3をターゲットにすることで,OABを治療することができます.

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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells09:04

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