Lactobacillus acidophilus KBL409は,ヒトの研究で腸内微生物の変化を介して血清インドキシル硫酸を改善する
Sung Jae Jang1,2, SungJun Park3,4,5, Kiuk Lee6
1Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
NPJ science of food
|February 16, 2026
まとめ
Lactobacillus acidophilus KBL409は,慢性腎臓病患者の血清インドキシル硫酸塩濃度を著しく低下させた. このプロバイオティクスの介入は腸内微生物群を調節し,腎臓の健康を改善するための潜在的な戦略を提供しました.
科学分野:
- 微生物学 微生物学とは
- ネフロロジーはネフロロジーを用います.
- 胃腸内科 胃腸内科
背景:
- 慢性腎臓病 (CKD) は,進行的な腎臓機能の低下と尿性毒素の蓄積を伴う.
- 腸腎軸は,腸内微生物群とCKDの進行との間の重要な相互作用を強調しています.
- インドキシル硫酸 (IS) のような尿性毒素は,CKDの合併症に寄与する.
研究 の 目的:
- 慢性腎臓病患者の尿中毒素濃度の低下におけるLactobacillus acidophilus KBL409の有効性を評価する.
- L. acidophilus KBL409が腸内微生物の組成に及ぼす影響と,尿性毒素との関係性を調査する.
主な方法:
- マルチセンター,ランダム化,ダブルブラインド,プラセボ対照試験が行われました.
- 参加者は16週間,毎日L. acidophilus KBL409 (1x10^10 CFU) またはプラセボを投与されました.
- 血清のISレベルと腸内微生物の組成を分析した.
主要な成果:
- 血清のIS濃度は,プラセボと比較してL. acidophilus KBL409群で有意に低かった (p<0.05).
- 特定の腸内細菌の属 (ブラウチア,ブティリチココックス,ラックノスピラセア UCG-004,メガモナス) の有意な減少が観察されました.
- これらのバクテリアは,尿性毒素合成経路における予測された遺伝子との正の相関を示した.
結論:
- L. acidophilus KBL409は,CKD患者の血清インドキシル硫酸塩濃度を効果的に低下させます.
- プロバイオティックは腸内微生物の組成を調節し,尿性毒素合成に影響を与えます.
- L. acidophilus KBL409は,腸内微生物群の調節による腎臓の健康管理のための有望なプロバイオティックアプローチを示しています.
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