ニューロパシー性疼痛に対するGlyT2の可逆性アロステリック阻害剤で,標的上の副作用はありません

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Updated: Feb 18, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Ryan P Cantwell Chater1,2, Julian Peiser-Oliver2, Tanmay K Pati3

  • 1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Nature communications
|February 16, 2026
PubMed
まとめ

研究者らは,可逆性GLYT2阻害剤であるRPI-GLYT2-82を開発し,副作用なく痛みを和らげるという. このブレークスルーにより,神経病痛を標的とした新しい非オピオイド鎮痛剤の構造ベースの設計が可能になりました.

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