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Updated: Feb 18, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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クラスタリングとコンフォメーションスイッチは,哺乳類の受容体チロシンキナーゼROS1の誘発活性化を促します

Hengyi Li1,2, Jianan Zhang1,2, Tongqing Li1,2

  • 1Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.

Nature communications
|February 16, 2026
PubMed
まとめ

研究者らは,NELL2がROS1 (受容体チロシンキナーゼ) を,クラスタ化および構成変化を誘発することによって,どのように活性化するかを明らかにした. この発見は,ROS1駆動がんを標的とした新しい生物学的療法への道を開く.

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