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関連する概念動画

CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

2.0K
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
2.0K
CRISPR and crRNAs02:53

CRISPR and crRNAs

19.2K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
19.2K
CRISPR01:59

CRISPR

58.1K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
58.1K
Homologous Recombination02:31

Homologous Recombination

63.8K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
63.8K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.9K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.9K
What is Genetic Engineering?00:49

What is Genetic Engineering?

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Overview
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関連する実験動画

Updated: Feb 18, 2026

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

35.9K

コンピューティングとディープラーニングによるCRISPRゲノム編集の進歩

Chinmai Pindi1, Giulia Palermo2,3

  • 1Department of Bioengineering, University of California, Riverside, Riverside, CA, USA.

Nature structural & molecular biology
|February 16, 2026
PubMed
まとめ

ディープラーニングとコンピューティングツールは,医学とバイオテクノロジーのためのCRISPR遺伝子編集技術に革命を起こしています. これらの高度な方法は,正確なゲノム編集アプリケーションのためのCRISPRシステムの設計,最適化,理解を支援します.

さらに関連する動画

Genome Editing in Mammalian Cell Lines using CRISPR-Cas
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Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Published on: April 11, 2019

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CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

2.5K

関連する実験動画

Last Updated: Feb 18, 2026

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

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Genome Editing in Mammalian Cell Lines using CRISPR-Cas
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Genome Editing in Mammalian Cell Lines using CRISPR-Cas

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CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

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科学分野:

  • バイオテクノロジー バイオテクノロジー
  • 遺伝学 遺伝学とは
  • コンピュータ生物学 コンピュータ生物学

背景:

  • CRISPR-Casシステムは,医学,分子生物学,バイオテクノロジーを変革する強力なツールです.
  • CRISPRシステムのエンジニアリングと最適化は,その有効なアプリケーションにとって極めて重要です.

研究 の 目的:

  • CRISPR遺伝子編集の進歩におけるコンピューティングモデリングとディープラーニングの役割を検討する.
  • CRISPRシステムの理解とエンジニアリングにおける様々なコンピューティングツールの応用について議論する.

主な方法:

  • ディープラーニングベースの構造予測アルゴリズム
  • 物理ベースのシミュレーションです.
  • ニューラルネットワークとグラフニューラルネットワーク
  • 生成モデル (拡散モデル,大型言語モデル)

主要な成果:

  • コンピューティングツールは,CRISPRシステムの設計と最適化に大きく貢献しています.
  • これらの方法は,CRISPR-Casシステムのメカニズム的基礎の理解を深める.
  • コンピューティング・モデリングの進歩は,プログラム可能なゲノムエディタの開発の鍵です.

結論:

  • コンピューティング・モデリングとディープ・ラーニングは,CRISPR技術の進歩に不可欠です.
  • ゲノム編集のためのコンピューティングツールの潜在能力を完全に実現するには,課題と制限が存在します.
  • コンピューティングアプローチの継続的な開発は,CRISPRベースの生物医学とバイオテクノロジーのイノベーションを推進します.