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Updated: Feb 18, 2026

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
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遺伝子毒性試験ガイドラインからのデータの変動性と不確実性:私たちが知っていること,そしてなぜそれが重要なのか

Giuseppa Raitano1, Tessa E Pronk2, Chiara L Battistelli3

  • 1Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Archives of toxicology
|February 16, 2026
PubMed
まとめ

遺伝子毒性試験のデータは有意な変動性を示し,非動物用メソッド (NAM) の統合に影響を与えています. このデータの不確実性を理解することは,規制上の遺伝子毒性評価におけるNAMの検証に不可欠です.

キーワード:
遺伝子毒性について非動物を使った方法OECDは,OECDが,OECDが,OECDが,OECDが,テストガイドライン テストガイドライン不確実性 不確実性とは変数性 (variability) とは,変化の度合いを決定する.

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