PFASとワンヘルス:人間,動物,環境の観点を統合する
Marília Cristina Oliveira Souza1, Fernando Barbosa2, Jose L Domingo3
1School of Pharmaceutical Sciences of Ribeirão Preto, Department of Biomolecular Sciences, University of São Paulo, Av. do Café s/n, Ribeirao Preto, SP, 14040-903, Brazil.
Archives of toxicology
|February 16, 2026
まとめ
パーおよびポリフッ化アルキル物質 (PFAS) は,人間,動物,環境の健康を脅かす持続性,生物蓄積性の化学物質です. 統合された"ワン・ヘルス"のアプローチは,すべての生態系と集団におけるこれらの複雑なリスクの管理に不可欠です.
科学分野:
- 環境科学 環境科学
- 毒理学 毒理学 毒理学
- 公衆衛生は公衆衛生である.
背景:
- パーおよびポリフッ化アルキル物質 (PFAS) は,どこにでも存在し,持続性があり,生物蓄積性の化学物質です.
- 劣化への耐性と地球規模での分散は,リスク管理に包括的なアプローチを必要とします.
- PFASは,人間,動物,環境の健康に重大な脅威をもたらす.
研究 の 目的:
- PFASに関する現在の知識,その起源,持続性,拡散などを見直す.
- 種間における被曝経路と毒性学的結果に関する情報を合成する.
- PFASのリスクに対処するための統合された"ワン・ヘルス"の枠組みを提唱する.
主な方法:
- PFASに関する現在の科学的知識を統合した文献レビュー.
- 環境の持続性,世界的な分散,および暴露経路の分析.
- 毒性学的データの評価と種間リスク評価.
主要な成果:
- PFASは,人為的な源から発生し,世界中に分散しています.
- 曝露は,食事,汚染された水,母から母への感染を通じて発生します.
- 収束する毒性学的アウトカムには,免疫毒性,生殖機能障害,および種間の発がん性が含まれます.
結論:
- "ワン・ヘルス"の枠組みは,PFASの相互依存のリスクを管理するために不可欠です.
- 環境モニタリング,研究,規制を含む統合戦略が必要である.
- 調和した規制枠組みと分野間の協力は,効果的なPFAS緩和に不可欠です.
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