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Updated: Feb 18, 2026

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エニアチンB1のインビトロ肝臓クリアランス:種間および細胞モデルの比較

M Mahdjoub1, E Dubreil2, C Gendre2

  • 1Fougères Laboratory, ANSES French Agency for Food, Environmental and Occupational Health and Safety, Fougères - Rennes, France. mariam.mahdjoub@anses.fr.

Archives of toxicology
|February 16, 2026
PubMed
まとめ

エニアチンB1 (EnnB1) 菌毒素のクリアランスは,ラットでは人間よりも速い. 従来の枯渇測定法では,EnnB1の肝臓クリアランス (ClH) が正確に決定され,リスク評価に極めて重要です.

キーワード:
細胞モデル 細胞モデルエニアチンB1について肝臓のクリアランスはインビトロ (in vitro) とは種間関係である.

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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
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Hepatic clearance refers to the volume of blood cleared of a drug by the liver per unit of time. It plays a crucial role in drug metabolism and elimination. While hepatic clearance is commonly estimated by subtracting renal clearance from total body clearance, other pathways, such as pulmonary or biliary clearance, may also contribute. However, these pathways are generally less significant than hepatic and renal clearance.
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