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Updated: Feb 18, 2026

Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules
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Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules

Published on: April 25, 2025

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14-3-3ζはFOXO3aのDNA結合ドメインと相互作用し,ダブルモチーフテザリングによってDNAを競争的に解離する

Shota Enomoto1, Tomoya Kuwayama1, Shoichi Nakatsuka1

  • 1Graduate School of Pharmaceutical Sciences, Keio University 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.

Nature communications
|February 16, 2026
PubMed
まとめ

14-3-3ζタンパク質が酸化されたFOXO3a (腫瘍抑制剤) に結合すると,DNAから離され,アポトーシスが停止します. この研究は,14-3-3ζがDNA結合に直接競争し,癌細胞の増殖を抑制することを明らかにしています.

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