重篤な疾患における平均動脈圧のターゲティングとモニタリング: 混合メソッドのサービス評価
Isla MacKay1, Ian Piper2, Annemarie B Docherty2
1Edinburgh Medical School, University of Edinburgh, U.
Journal of the Intensive Care Society
|February 17, 2026
まとめ
集中治療室 (ICU) での最適な平均動脈圧 (MAP) 目標に関する臨床的見解は様々で,実際には個別化が限られている. 低血圧は一般的であり,個別化された血圧管理戦略の必要性を強調しています.
科学分野:
- クリティカルケア・メディシン
- 心血管生理学 心血管の生理学
- ネフロロジーはネフロロジーを用います.
背景:
- セプシスと心停止における動脈低血圧は,腎臓損傷と死亡率を含む有害な結果と関連しています.
- 現在のガイドラインでは,平均動脈圧 (MAP) の目標値が65mmHgであることを示唆しているが,証拠は限られている.
- 最適なMAP目標に関する臨床的見解を評価し,集中治療室 (ICU) での遵守を評価するために,サービス評価が行われました.
研究 の 目的:
- 最適な平均動脈圧 (MAP) 目標に関する集中治療室 (ICU) のコンサルタントの意見を評価する.
- MAP目標の遵守を評価し,エジンバラ王立病院ICUでの低血圧を定量化する.
主な方法:
- コンサルタントとの半構造面接と患者データの定量分析を組み合わせた,同時三角化混合方法のアプローチが採用されました.
- 患者の血圧データは,動脈モニタリングの最初の72時間間隔で1分間隔で収集されました.
- 低圧的侮辱は,MAPの目標値を下回る5分連続した侮辱と定義された.
主要な成果:
- 18人のコンサルタントとのインタビューでは,MAPの標準目標である65mmHgを67%が報告しており,個別化された柔軟な目標の必要性を強調しています.
- 66人の患者の208,570分間のモニタリングデータを分析した結果,患者の83%が低血圧を患ったことが判明しました.
- 静脈圧縮剤を投与された患者では,静脈圧縮剤を投与しなかった患者と比較して,平均動脈圧は有意に低下した (77.6 mmHg vs 86.9 mmHg,p=0.0001).
結論:
- 最適なMAPターゲットは患者に依存しますが,ターゲットのパーソナライゼーションは臨床実務において依然として困難です.
- MAPの目標への遵守は変動し,観測された圧力は既定レベルを超えたり,下りたりした.
- 将来の研究は,より正確な血圧制御を達成する可能性と影響を調査する必要があります.
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