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Updated: Jul 19, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

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マルチドラッグレジスタンスのタンパク質1を,その柔軟なインタードメインリンクナーを,配列選択ペプチド結合ナノ粒子と結合することによって抑制する

Avijit Ghosh1, Mansi Sharma1, Yan Zhao1

  • 1Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, United States.

Biomacromolecules
|February 17, 2026
PubMed
まとめ

分子インプリントされたナノ粒子は,多剤耐性タンパク質1 (MRP1) を標的とし,がん薬剤耐性を克服します. この新しいアプローチは,流出ポンプを阻害し,化学療法に耐性のあるがん細胞を感知させ,薬のIC50値を低下させます.

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