セルフィング nematode Caenorhabditis elegansの局所個体群における数年の間における突然変異の差異

Xu Wei1,2, Aurélien Richaud1, Robyn E Tanny3

  • 1Institut de Biologie de l'École Normale Supérieure, Centre National de la Recherche Scientifique, 46 rue d'Ulm, 75005 Paris, France.

Genetics
|February 17, 2026
PubMed
まとめ

この研究では,天然のCaenorhabditis elegans集団の変異を13年にわたって追跡しました. 塩基対1年あたり4-5x10^-8の変異率を推定し,限られた分散を観察し,時空的なパターンを明らかにしました.

関連する概念動画

Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.2K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
64.7K
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.7K