慢性外傷性潰瘍におけるp16とMGMTメチル化:慢性機械的刺激と口腔がん発生の間の合理的な関連性?
Jeronimo Pablo Lazos1, Marcela Hernandez Rios2, Jessica Astorga2
1Oral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Córdoba, Argentina.
まとめ
慢性機械刺激 (CMI) は,口腔組織におけるp16およびMGMT遺伝子メチル化を著しく増加させる. CMIの管理は,これらの表遺伝的変化を減らすことによって,口腔がんを予防するのに役立ちます.
科学分野:
- 口腔病理学について
- 癌のエピジェネティクス
- 分子生物学は分子生物学である.
背景:
- 慢性機械刺激 (CMI) は,口腔がんのリスク要因の1つと考えられています.
- DNAメチル化のようなエピジェネティック変異は,がんの発症の初期イベントです.
- CMIはこれらの表遺伝的変化を誘発し,慢性外傷性潰瘍 (CTU) のp16とMGMTメチル化に関する調査を促す可能性があります.
研究 の 目的:
- 慢性外傷性潰瘍 (CTU) に罹患した口腔粘膜におけるp16およびMGMT遺伝子のメチル化状態を調査および記述する.
主な方法:
- 27人の参加者を対象としたケース・コントロール・スプリット・マウス研究.
- 剥離性サイトロジーは,CTUと逆側正常粘膜からサンプルを採取するために使用されました.
- DNAは,qPCRとシーケンシングを使用してp16とMGMTプロモーターメチレーションを分析した.
主要な成果:
- 患者の平均年齢は59.1歳でした.
- CTUでp16 (85%対20%) とMGMT (80%対24%) のメチル化が正常粘膜と比較して著しく高かったことが観察されました (p < 0.0001とp < 0.0005,それぞれ).
結論:
- CMIへの継続的な曝露は,口腔粘膜におけるp16およびMGMTメチル化の増加と関連しています.
- 機械的傷害要因の管理は,口腔状細胞癌 (OSCC) の予防に決定的な役割を果たす可能性があります.
- 脱皮性細胞学と分口設計は,CMIのバイオマーカーを研究するための有効なツールですが,CMIの口腔がん発生における役割に関するさらなる研究が必要です.
キーワード:
MGMTMGMTMGMT MGMTMGMT MGMTMGMTMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM慢性的な機械的刺激メチル化のメチル化口腔がんは口腔がんである.p16 p16 p16 p16 p16 P16 P16 P16 P16 P16 P16 P16 P16 P16 P16 P16 P16さらに関連する動画
04:12Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
15.4K
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
12.4K
関連する概念動画
Peptic Ulcer Disease I: Introduction
905
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
905
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
1.3K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.3K
Peptic Ulcer Disease IV: Management
546
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
546
