慢性外傷性潰瘍におけるp16とMGMTメチル化:慢性機械的刺激と口腔がん発生の間の合理的な関連性?

Jeronimo Pablo Lazos1, Marcela Hernandez Rios2, Jessica Astorga2

  • 1Oral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Córdoba, Argentina.

まとめ

慢性機械刺激 (CMI) は,口腔組織におけるp16およびMGMT遺伝子メチル化を著しく増加させる. CMIの管理は,これらの表遺伝的変化を減らすことによって,口腔がんを予防するのに役立ちます.

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